Has to do with IPV6 being disabled, but it’s not disabled correctly.
Go to the following key in the Windows 2008 Machine
Create if there is not one a DWORD (32 Bit) entry with the following payload
Dword Name = DisabledComponents
Payload = ffffffff
(that is 8 f’s)
It will register as 0xffffffff as a hexidecimal value.
Reboot. This resolved my issues with the Mailstore not coming online after disabling IPV6 in the network adapter.